Date: Monday, February 23, 2015
Location: 1866 East Hall (3:00 PM to 4:00 PM)
Title: Mathematical Modeling in Epidemiology: HPV and Oral Cancer
Abstract: Age-period-cohort (APC) models aim to disentangle the three kinds of temporal effects seen in epidemiological time-series data, but are inherently unidentifiable and are not rooted in any underlying biology. Multistage clonal expansion models (MSCE), a developed by coupling a non-homogeneous Poisson process with a birth-death-mutation process, are well-validated and are grounded in the mechanisms of tumorigenesis. Using a hybrid APC-MSCE model approach, we investigate incidence of three types of oral cancer.
Speaker: Andrew Brouwer