Date: Monday, December 08, 2014
Location: 3096 East Hall (3:00 PM to 4:00 PM)
Title: Fast and slow coupling in the mammalian circadian clock
Abstract: The mammalian circadian (daily) clock is controlled by the ~20,000 neurons of the suprachiasmatic nuclei (SCN). While the molecular mechanisms for generating rhythms in individual SCN neurons are well characterized, single-cell rhythms are weak and noisy, and it is still unknown how they are integrated to generate robust rhythms at the tissue level. To investigate this, we develop a highly detailed, multicellular, and multi-scale model of the SCN. The model is used to investigate, and make predictions about, the differential roles of fast GABAergic synaptic coupling, and slower paracrine signaling through VIP, which couple neurons in the SCN.
Speaker: Dan DeWoskin